- Other groups
- Regulatory Genomics
- Chromatin and Cell Fate
- Disease Genomics
- Epigenetic Mechanisms of Cancer and Cell Differentiation
- Cancer Genetics and Epigenetics
- Cancer and Iron
- ICO-IMPPC Joint Program - Genetic Diagnostics
- Genetic Variation and Cancer
- Genomics and Bioinformatics
- ABO Histo-Blood Groups and Cancer
- Cancer Genome Biology
Tanya Vavouri and the Regulatory Genomics Group are now part of the Josep Carreras Leukaemia Research Institute.
In the past we have analysed data from yeast to human to understand why some genes are harmful when they are overexpressed. Increased gene dosage, as for example by gene amplification, is associated with diverse human pathologies, including cancer. We have also studied the origins and stability of genetic redundancy, the phenomenon whereby mutations in many genes have little effect on an organism. A better understanding of genetic redundancy, or buffering, may offer insight into how to target cancer cells where this redundancy is failing.
More recently we have shown that sequence composition determines the packaging of the human genome in the male germline. GC-rich sequences remain packaged in nucleosomes in the male gametes. This raises the possibility that at these GC-rich sites epigenetic information can be transmitted from one generation to the next. Understanding how and to what extent epigenetic information can be transmitted between generations is important because in the long term it may help us predict better disease risk in individuals.
We are currently studying how the promoter type of human genes affects their chromatin organization. We recently showed that genes with CpG-island promoters have distinct chromatin from genes with other types of promoter. Cancer cells often have very different epigenetic marks from normal cells. Our aim is to understand how global epigenetic changes, associated with cancer or induced by anti-cancer therapeutic drugs, affect the regulation of different types of human genes.
2014 Spanish National Postdoctoral Fellowship (MINECO) to Yulia Medvedeva
2014 Max Planck - Prince of Asturias Award Mobility Grant to Eduard Casas
2014 Group recognized by the Catalan Research Agency (AGAUR)
2014 EpiGeneSys Travel Fellowship to Eduard Casas
2013 Elected Associate Member of the EU Network of Excellence EpiGeneSys
2011 Spanish National Research Grant (MICINN)
2011 European Reintegration Grant - Framework Programme 7
2010 Ramon y Cajal Award to Tanya Vavouri
Tanya Vavouri (email@example.com)
Office 1- 5 (first floor)
Tel: (+34) 93 554 3078