Summary

The Epigenetic Mechanisms of Cancer and Cell Differentiations Group now forms part of the Program for Predictive and Personalized Medicine of Cancer at the Institute Germans Trias i Pujol (IGPT) on the Can Ruti Campus. The name of the group is now  Please see the IGTP website here.

 

Recent discoveries and improved techniques are creating a new scene, where epigenetic features, such as the structure and activity of chromatin, are being defined. This information will help us to understand how genomic information is regulated and interpreted in physiological situations, such as development; or pathologies, such as cancer.

Our research centers on the molecular characterization of progression in colorectal cancer and the identification of molecular markers with clinical applications (risk, diagnostics and prognostics). Within the fields of Genomics and Epigenomics our current interests are:

  • Identification and study of chromosomal regions which are silenced in tumor cells.
  • Description of the epigenetic mechanisms that regulate repetitive elements and how these elements participate in biological processes, amongst them cancer.
  • Study of the interaction between epigenetics and genetic instability, and how changes in the structure of chromatin can affect the integrity of the genome and facilitate or induce cancer.

In addition, our group aims to contribute to the advance of Genomic Medicine by developing new technologies and bioinformatic tools (more info at https://maplabcat.wordpress.com/). The group has created the spin-off Aniling (www.aniling.com) focused on the improvement of Next Generation Sequencing methods.

Group Members:

Previous Members of Lab:


Projects

  • Epigenetics: Mechanisms and disease

    Investigador principalFinanciamientoFecha de inicioFecha de finalización
    Miguel A. Peinado MICINN01-01-200924-09-2012
  • Definition and Characterization of Epigenetic Domains in normal and Tumoral Cells.

    Investigador principalFinanciamientoFecha de inicioFecha de finalización
    Miguel A. Peinado MICINN01-01-200931-12-2011
  • Epigenetics and cancer

    Investigador principalFinanciamientoFecha de inicioFecha de finalización
    Miguel A. Peinado AGAUR01-01-200931-12-2013
  • A Genetic Map of Repetetive DNA in Cancer

    Investigador principalFinanciamientoFecha de inicioFecha de finalización
    Mireia Jordà Merck01-03-200928-02-2012
  • Insights into the role of Alu repeats in the epigenomic architecture of variability and cancer

    Investigador principalFinanciamientoFecha de inicioFecha de finalización
    Miguel A. Peinado MICINN01-01-201231-12-2014
  • Technician Contract

    Investigador principalFinanciamientoFecha de inicioFecha de finalización
    Miguel A. Peinado MICINN01-01-201231-12-2014
  • Myogenesis and bivalent domains (abbreviated title)

    Investigador principalFinanciamientoFecha de inicioFecha de finalización
    Mònica Suelves MICINN01-01-201031-12-2012
  • Epigenetic dynamics during myogenesis: role in cellular identity, cell activation and terminal differentiation

    Investigador principalFinanciamientoFecha de inicioFecha de finalización
    Mònica Suelves MICINN01-01-201331-12-2015
  • Retos Colaboración 2015

    Investigador principalFinanciamientoFecha de inicioFecha de finalización
    Miguel A. Peinado El Ministerio de Economía y Competitividad español (MINECO), dentro del Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016, concedió ayuda al proyecto “GEUS, desarrollo de tecnología para el análisis unificado de genoma y epigenoma de alta precisión” liderado por Aniling con número de expediente RTC-2015-3867-1. Este proyecto ha sido financiado por el Ministerio de Economía y Competitividad (MINECO) dentro del Subprograma RETOS-COLABORACIÓN, Convocatoria 2015. El proyecto está cofinanciado por la Unión Europea con el objetivo de promover el desarrollo tecnológico, la innovación y una investigación de calidad. 01-01-201631-12-2017

Contacto

mpeinado@imppc.org

Office 2-2, Lab 2-1 (second floor)

(+34) 93 554 3050


Epigenetic Mechanisms of Cancer and Cell Differentiation

Publicaciones relevantes

Suelves M, Carrió E, Núñez-Álvarez Y, Peinado MA. DNA methylation dynamics in cellular commitment and differentiation. Brief Funct Genomics 2016 Jun;

Carrió E, Magli A, Muñoz M, Peinado MA, Perlingeiro R, Suelves M. Muscle cell identity requires Pax7-mediated lineage-specific DNA demethylation. BMC Biol. 2016; 14: 30

Díez-Villanueva A, Mallona I, Peinado MA. Wanderer, an interactive viewer to explore DNA methylation and gene expression data in human cancer. Epigenetics Chromatin 2015; 8: 22

Forn M, Díez-Villanueva A, Merlos-Suárez A, Muñoz M, Lois S, Carrió E, Jorda M, Bigas A, Batlle E, Peinado MA. Overlapping DNA methylation dynamics in mouse intestinal cell differentiation and early stages of malignant progression. PLoS ONE 2015; 10(5): e0123263

Carrió E, Díez-Villanueva A, Lois S, Mallona I, Cases I, Forn M, Peinado MA, Suelves M. Deconstruction of DNA methylation patterns during myogenesis reveals specific epigenetic events in the establishment of the skeletal muscle lineage. Stem Cells 2015 Mar;

Mallona I, Díez-Villanueva A, Peinado MA. Methylation plotter: a web tool for dynamic visualization of DNA methylation data. Source Code Biol Med 2014; 9: 11

Abraham J, Núñez-Álvarez Y, Hettmer S, Carrió E, Chen HI, Nishijo K, Huang ET, Prajapati SI, Walker RL, Davis S, Rebeles J, Wiebush H, McCleish AT, Hampton ST, Bjornson CR, Brack AS, Wagers AJ, Rando TA, Capecchi MR, Marini FC, Ehler BR, Zarzabal LA, Goros MW, Michalek JE, Meltzer PS, Langenau DM, LeGallo RD, Mansoor A, Chen Y, Suelves M, Rubin BP, Keller C. Lineage of origin in rhabdomyosarcoma informs pharmacological response. Genes Dev. 2014 Jul; 28(14): 1578-91

Barrera V, Peinado MA. Evaluation of single CpG sites as proxies of CpG island methylation states at the genome scale. Nucleic Acids Res. 2012 Oct;

Cebola I, Peinado MA. Epigenetic deregulation of the COX pathway in cancer. Prog. Lipid Res. 2012 Oct; 51(4): 301-13

Mayor R, Muñoz M, Coolen MW, Custodio J, Esteller M, Clark SJ, Peinado MA. Dynamics of bivalent chromatin domains upon drug induced reactivation and resilencing in cancer cells. Epigenetics 2011 Sep; 6(9)

Mayor R, Casadomé L, Azuara D, Moreno V, Clark SJ, Capellà G, Peinado MA. Long-range epigenetic silencing at 2q14.2 affects most human colorectal cancers and may have application as a non-invasive biomarker of disease. Br. J. Cancer 2009 May; 100(10): 1534-9

Morales C, García MJ, Ribas M, Miró R, Muñoz M, Caldas C, Peinado MA. Dihydrofolate reductase amplification and sensitization to methotrexate of methotrexate-resistant colon cancer cells. Mol. Cancer Ther. 2009 Feb; 8(2): 424-32

Rodriguez J, Muñoz M, Vives L, Frangou CG, Groudine M, Peinado MA. Bivalent domains enforce transcriptional memory of DNA methylated genes in cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2008 Dec; 105(50): 19809-14

Rodriguez J, Vives L, Jorda M, Morales C, Muñoz M, Vendrell E, Peinado MA. Genome-wide tracking of unmethylated DNA Alu repeats in normal and cancer cells. Nucleic Acids Res. 2008 Feb; 36(3): 770-84

Wang Y, Jorda M, Jones PL, Maleszka R, Ling X, Robertson HM, Mizzen CA, Peinado MA, Robinson GE. Functional CpG methylation system in a social insect. Science 2006 Oct; 314(5799): 645-7


Ver todas

Generalitat de Catalunya

Unió Europea

CSIC

Universitat Autònoma de Barcelona

Ajuntament de Badalona

Institut Català de la Salut

Germans Trias i Pujol Hospital

Fundació Institut d'investigació en Ciències de la Salut Germans Trias i Pujol

Back to Top