Summary

The Epigenetic Mechanisms of Cancer and Cell Differentiations Group now forms part of the Program for Predictive and Personalized Medicine of Cancer at the Institute Germans Trias i Pujol (IGPT) on the Can Ruti Campus. The name of the group is now  Please see the IGTP website here.

 

Recent discoveries and improved techniques are creating a new scene, where epigenetic features, such as the structure and activity of chromatin, are being defined. This information will help us to understand how genomic information is regulated and interpreted in physiological situations, such as development; or pathologies, such as cancer.

Our research centers on the molecular characterization of progression in colorectal cancer and the identification of molecular markers with clinical applications (risk, diagnostics and prognostics). Within the fields of Genomics and Epigenomics our current interests are:

  • Identification and study of chromosomal regions which are silenced in tumor cells.
  • Description of the epigenetic mechanisms that regulate repetitive elements and how these elements participate in biological processes, amongst them cancer.
  • Study of the interaction between epigenetics and genetic instability, and how changes in the structure of chromatin can affect the integrity of the genome and facilitate or induce cancer.

In addition, our group aims to contribute to the advance of Genomic Medicine by developing new technologies and bioinformatic tools (more info at https://maplabcat.wordpress.com/). The group has created the spin-off Aniling (www.aniling.com) focused on the improvement of Next Generation Sequencing methods.

Group Members:

Previous Members of Lab:

  • Raquel Buj
  • Belén Sánchez
  • Elvira Carrió
  • Anna Díez-Villanueva
  • Mireia Jordà
  • Joaquim Custodio
  • Marta Forn
  • Víctor Barrera
  • Inês Cebola
  • Regina Mayor
  • Sergi Lois
  • Laura Vives
  • Jairo Rodríguez
  • Elena Gómez-Díaz
  • Gemma Aiza
  • Cristina Morales
  • Maria Ribas
  • Elisenda Vendrell
  • Jordi Frigola
  • Rosa-Ana Risques
  • Laia Masramon
  • Gloria Julià
  • Olga Campos
  • Isabel González
  • Silvia Tórtola
  • Rosa Arribas

Projects

  • Functional anatomy of cancer epigenomic architecture / SAF 2015-64521-R

    Investigador principalFinançadorsData d'iniciData de finalització
    Miguel A. Peinado MINECO01-01-201631-12-2018
  • GEUS: Unified analysis of genome and epigenome with high fidelity / M.A. Peinado/L. Coll/ V. Moreno / RTC-2015-3867-1

    Investigador principalFinançadorsData d'iniciData de finalització
    Miguel A. Peinado MINECO01-01-201531-12-2018
  • A new mechanism of action of Azacitidine beyond DNA hypomethylation in human cancer. A pilot study. GRANT-ESP-063

    Investigador principalFinançadorsData d'iniciData de finalització
    Miguel A. Peinado Celgene SL 01-01-201731-12-2018
  • Deciphering the contribution of epigenetic modifiers in muscle cell identity, differentiation and growth / BFU2016-80748-P

    Investigador principalFinançadorsData d'iniciData de finalització
    Mònica Suelves MINECO01-01-201731-12-2019

Contacte

mpeinado@imppc.org

Office 2-2, Lab 2-1 (second floor)

(+34) 93 554 3050


Epigenetic Mechanisms of Cancer and Cell Differentiation

Publicacions rellevants

Suelves M, Carrió E, Núñez-Álvarez Y, Peinado MA. DNA methylation dynamics in cellular commitment and differentiation. Brief Funct Genomics 2016 Jun;

Carrió E, Magli A, Muñoz M, Peinado MA, Perlingeiro R, Suelves M. Muscle cell identity requires Pax7-mediated lineage-specific DNA demethylation. BMC Biol. 2016; 14: 30

Díez-Villanueva A, Mallona I, Peinado MA. Wanderer, an interactive viewer to explore DNA methylation and gene expression data in human cancer. Epigenetics Chromatin 2015; 8: 22

Forn M, Díez-Villanueva A, Merlos-Suárez A, Muñoz M, Lois S, Carrió E, Jorda M, Bigas A, Batlle E, Peinado MA. Overlapping DNA methylation dynamics in mouse intestinal cell differentiation and early stages of malignant progression. PLoS ONE 2015; 10(5): e0123263

Carrió E, Díez-Villanueva A, Lois S, Mallona I, Cases I, Forn M, Peinado MA, Suelves M. Deconstruction of DNA methylation patterns during myogenesis reveals specific epigenetic events in the establishment of the skeletal muscle lineage. Stem Cells 2015 Mar;

Mallona I, Díez-Villanueva A, Peinado MA. Methylation plotter: a web tool for dynamic visualization of DNA methylation data. Source Code Biol Med 2014; 9: 11

Abraham J, Núñez-Álvarez Y, Hettmer S, Carrió E, Chen HI, Nishijo K, Huang ET, Prajapati SI, Walker RL, Davis S, Rebeles J, Wiebush H, McCleish AT, Hampton ST, Bjornson CR, Brack AS, Wagers AJ, Rando TA, Capecchi MR, Marini FC, Ehler BR, Zarzabal LA, Goros MW, Michalek JE, Meltzer PS, Langenau DM, LeGallo RD, Mansoor A, Chen Y, Suelves M, Rubin BP, Keller C. Lineage of origin in rhabdomyosarcoma informs pharmacological response. Genes Dev. 2014 Jul; 28(14): 1578-91

Barrera V, Peinado MA. Evaluation of single CpG sites as proxies of CpG island methylation states at the genome scale. Nucleic Acids Res. 2012 Oct;

Cebola I, Peinado MA. Epigenetic deregulation of the COX pathway in cancer. Prog. Lipid Res. 2012 Oct; 51(4): 301-13

Mayor R, Muñoz M, Coolen MW, Custodio J, Esteller M, Clark SJ, Peinado MA. Dynamics of bivalent chromatin domains upon drug induced reactivation and resilencing in cancer cells. Epigenetics 2011 Sep; 6(9)

Mayor R, Casadomé L, Azuara D, Moreno V, Clark SJ, Capellà G, Peinado MA. Long-range epigenetic silencing at 2q14.2 affects most human colorectal cancers and may have application as a non-invasive biomarker of disease. Br. J. Cancer 2009 May; 100(10): 1534-9

Morales C, García MJ, Ribas M, Miró R, Muñoz M, Caldas C, Peinado MA. Dihydrofolate reductase amplification and sensitization to methotrexate of methotrexate-resistant colon cancer cells. Mol. Cancer Ther. 2009 Feb; 8(2): 424-32

Rodriguez J, Muñoz M, Vives L, Frangou CG, Groudine M, Peinado MA. Bivalent domains enforce transcriptional memory of DNA methylated genes in cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2008 Dec; 105(50): 19809-14

Rodriguez J, Vives L, Jorda M, Morales C, Muñoz M, Vendrell E, Peinado MA. Genome-wide tracking of unmethylated DNA Alu repeats in normal and cancer cells. Nucleic Acids Res. 2008 Feb; 36(3): 770-84

Wang Y, Jorda M, Jones PL, Maleszka R, Ling X, Robertson HM, Mizzen CA, Peinado MA, Robinson GE. Functional CpG methylation system in a social insect. Science 2006 Oct; 314(5799): 645-7


Veure-les totes

Generalitat de Catalunya

Unió Europea

CSIC

Universitat Autònoma de Barcelona

Ajuntament de Badalona

Institut Català de la Salut

Germans Trias i Pujol Hospital

Fundació Institut d'investigació en Ciències de la Salut Germans Trias i Pujol

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