Epigenetic Mechanisms of Cancer and Cell Differentiation
- Other groups
- Chromatin and Cell Fate
- DNA Bank
- Epigenetic Mechanisms of Cancer and Cell Differentiation
- Cancer Genetics and Epigenetics
- Computational Biology and Bioinformatics
- Cancer and Iron
- ICO-IMPPC Joint Program - Genetic Diagnostics
- Genetic Variation and Cancer
- Genomics and Bioinformatics
- Regulatory Genomics
- ABO Histo-Blood Groups and Cancer
Summary
Recent discoveries and improved techniques are creating a new scene, where epigenetic features, such as the structure and activity of chromatin, are being defined. This information will help us to understand how genomic information is regulated and interpreted in physiological situations, such as development; or pathologies, such as cancer.
Our research centers on the molecular characterization of progression in colorectal cancer and the identification of molecular markers with clinical applications (risk, diagnostics and prognostics). Within the fields of Genomics and Epigenomics our current interests are:
- Identification and study of chromosomal regions which are silenced in tumor cells.
- Description of the epigenetic mechanisms that regulate repetitive elements and how these elements participate in biological processes, amongst them cancer.
- Study of the interaction between epigenetics and genetic instability, and how changes in the structure of chromatin can affect the integrity of the genome and facilitate or induce cancer.
Group Members:
-
Miguel A. Peinado
Senior Group Leader -
Mònica Suelves
Associate Investigator
Previous Members of Lab:
Projects
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Epigenetics: Mechanisms and disease
IP Funding Starts Ends Miguel A. Peinado MICINN 01-01-2009 24-09-2012 -
Definition and Characterization of Epigenetic Domains in normal and Tumoral Cells.
IP Funding Starts Ends Miguel A. Peinado MICINN 01-01-2009 31-12-2011 -
Epigenetics and cancer
IP Funding Starts Ends Miguel A. Peinado AGAUR 01-01-2009 31-12-2013 -
A Genetic Map of Repetetive DNA in Cancer
IP Funding Starts Ends Mireia Jordà Merck 01-03-2009 28-02-2012 -
Insights into the role of Alu repeats in the epigenomic architecture of variability and cancer
IP Funding Starts Ends Miguel A. Peinado MICINN 01-01-2012 31-12-2014 -
Technician Contract
IP Funding Starts Ends Miguel A. Peinado MICINN 01-01-2012 31-12-2014 -
Myogenesis and bivalent domains (abbreviated title)
IP Funding Starts Ends Mònica Suelves MICINN 01-01-2010 31-12-2012 -
Epigenetic dynamics during myogenesis: role in cellular identity, cell activation and terminal differentiation
IP Funding Starts Ends Mònica Suelves MICINN 01-01-2013 31-12-2015
Contact
Office 2-2, Lab 2-1 (second floor)
(+34) 93 554 3050
Selected Publications
Barrera V, Peinado MA. Evaluation of single CpG sites as proxies of CpG island methylation states at the genome scale. Nucleic Acids Res. 2012 Oct;
Cebola I, Peinado MA. Epigenetic deregulation of the COX pathway in cancer. Prog. Lipid Res. 2012 Oct; 51(4): 301-13
Mayor R, Muñoz M, Coolen MW, Custodio J, Esteller M, Clark SJ, Peinado MA. Dynamics of bivalent chromatin domains upon drug induced reactivation and resilencing in cancer cells. Epigenetics 2011 Sep; 6(9)
Jorda M, Peinado MA. Methods for DNA methylation analysis and applications in colon cancer. Mutat. Res. 2010 Nov; 693(1): 84-93
Mayor R, Casadomé L, Azuara D, Moreno V, Clark SJ, Capellà G, Peinado MA. Long-range epigenetic silencing at 2q14.2 affects most human colorectal cancers and may have application as a non-invasive biomarker of disease. Br. J. Cancer 2009 May; 100(10): 1534-9
Morales C, García MJ, Ribas M, Miró R, Muñoz M, Caldas C, Peinado MA. Dihydrofolate reductase amplification and sensitization to methotrexate of methotrexate-resistant colon cancer cells. Mol. Cancer Ther. 2009 Feb; 8(2): 424-32
Rodriguez J, Muñoz M, Vives L, Frangou CG, Groudine M, Peinado MA. Bivalent domains enforce transcriptional memory of DNA methylated genes in cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2008 Dec; 105(50): 19809-14
Rodriguez J, Vives L, Jorda M, Morales C, Muñoz M, Vendrell E, Peinado MA. Genome-wide tracking of unmethylated DNA Alu repeats in normal and cancer cells. Nucleic Acids Res. 2008 Feb; 36(3): 770-84
Wang Y, Jorda M, Jones PL, Maleszka R, Ling X, Robertson HM, Mizzen CA, Peinado MA, Robinson GE. Functional CpG methylation system in a social insect. Science 2006 Oct; 314(5799): 645-7
Insights into social insects from the genome of the honeybee Apis mellifera. Nature 2006 Oct; 443(7114): 931-49
Rodriguez J, Frigola J, Vendrell E, Risques RA, Fraga MF, Morales C, Moreno V, Esteller M, Capellà G, Ribas M, Peinado MA, Jorda M. Chromosomal instability correlates with genome-wide DNA demethylation in human primary colorectal cancers. Cancer Res. 2006 Sep; 66(17): 8462-9468
Frigola J, Song J, Stirzaker C, Hinshelwood RA, Peinado MA, Clark SJ. Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band. Nat. Genet. 2006 May; 38(5): 540-9
