Genomics and Bioinformatics
- Other groups
- Chromatin and Cell Fate
- DNA Bank
- Epigenetic Mechanisms of Cancer and Cell Differentiation
- Cancer Genetics and Epigenetics
- Computational Biology and Bioinformatics
- Cancer and Iron
- ICO-IMPPC Joint Program - Genetic Diagnostics
- Genetic Variation and Cancer
- Genomics and Bioinformatics
- Regulatory Genomics
- ABO Histo-Blood Groups and Cancer
Summary
The main goal of the Genomics Laboratory at the IMPPC will be to provide the institution with state of the art genomics and bioinformatics technologies to give support to the activities of its researchers. We envision the gradual implementation of platforms complemented by outsourcing and contracting of external services, emphasizing the building of a team of experts in experimental design and sample preparation, and in bioinformatic data analysis. We aim to develop new methods for the discovery and typing of novel molecular markers for cancer and other disease prediction, centering on the use of DNA polymorphisms (SNPs and CNVs), differential gene expression (specifically of miRNAs and other non-coding RNAs), and chromatin modifications (DNA methylation), and the generation of predictors based on genomic data that can have an application on cancer preventive medicine.
Our Research
Available Resources
Main emphasis will be in covering technological areas related to the study of nucleic acids with high throughput / high information content approaches, including the use of DNA chips or microarrays, genotyping assays, quantitative PCR based quantitation methods, and conventional, second and third generation DNA sequencing.
Collaborations
CRG, University of Barcelona, IDIBELL, CREAL, Hospital Trias i Pujol, IR Vall d'Hebron
Projects
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Use of miRNA Expression Profiles in Serum for the Study of Cancer Progression
IP Funding Starts Ends Lauro Sumoy ISCIII 01-01-2011 31-12-2013
Contact
Lauro Sumoy
lsumoy@imppc.org
(+34) 93 554 3075
Office 0-9 (ground floor)
Selected Publications
Llorens F, Hummel M, Pastor X, Ferrer A, Pluvinet R, Vivancos A, Castillo E, Iraola S, Mosquera AM, González E, Lozano J, Ingham M, Dohm JC, Noguera M, Kofler R, del Río JA, Bayés M, Himmelbauer H, Sumoy L. Multiple platform assessment of the EGF dependent transcriptome by microarray and deep tag sequencing analysis. BMC Genomics 2011; 12: 326
Martí E, Pantano L, Bañez-Coronel M, Llorens F, Miñones-Moyano E, Porta S, Sumoy L, Ferrer I, Estivill X. A myriad of miRNA variants in control and Huntington's disease brain regions detected by massively parallel sequencing. Nucleic Acids Res. 2010 Nov; 38(20): 7219-35
Pluvinet R, Olivar R, Krupinski J, Herrero-Fresneda I, Luque A, Torras J, Cruzado JM, Grinyó JM, Sumoy L, Aran JM. CD40: an upstream master switch for endothelial cell activation uncovered by RNAi-coupled transcriptional profiling. Blood 2008 Nov; 112(9): 3624-37
Puigdecanet E, Espinet B, Lozano JJ, Sumoy L, Bellosillo B, Arenillas L, Alvarez-Larrán A, Solé F, Serrano S, Besses C, Florensa L. Gene expression profiling distinguishes JAK2V617F-negative from JAK2V617F-positive patients in essential thrombocythemia. Leukemia 2008 Jul; 22(7): 1368-76
Llorens F, Gil V, Iraola S, Carim-Todd L, Martí E, Estivill X, Soriano E, del Río JA, Sumoy L. Developmental analysis of Lingo-1/Lern1 protein expression in the mouse brain: interaction of its intracellular domain with Myt1l. Dev Neurobiol 2008 Mar; 68(4): 521-41
Mengual L, Burset M, Ars E, Ribal MJ, Lozano JJ, Minana B, Sumoy L, Alcaraz A. Partially degraded RNA from bladder washing is a suitable sample for studying gene expression profiles in bladder cancer. Eur. Urol. 2006 Dec; 50(6): 1347-55; discussion 1355-6
De Nadal E, Zapater M, Alepuz PM, Sumoy L, Mas G, Posas F. The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes. Nature 2004 Jan; 427(6972): 370-4
Carim-Todd L, Escarceller M, Estivill X, Sumoy L. LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex. Eur. J. Neurosci. 2003 Dec; 18(12): 3167-82
