Summary

The Cancer Genome Biology Group is now the Genetic Epidemiology of Lung Cancer Group at the Institute Germans Trias i Pujol (IGTP).

Please see the IGTP website here

 

Lung cancer is the leading cause of cancer death worldwide. To improve the outcome of patients with lung cancer, it is indispensable to understand the molecular pathways of lung cancer development and its progression. In particular, small cell lung cancer (SCLC) is the most aggressive type of lung cancer and, to date, no targetable genetic alterations have been identified except for the MYC family genes. The leader of this group has a great deal of experience in studying the molecular genetics of lung cancer. Therefore, the purpose of this group's work is to identify molecular targets for new therapies for SCLC among genes that are genetically altered in SCLC cells and to develop new therapies by targeting those gene products in vivo.

Our Research

Identification of targetable genetic alterations for therapy in small cell lung cancer

To identify novel genes targetable as therapy of SCLC, several kinds of genome-wide analyses, including exome sequencing, DNA methylation microarrays and splicing microarrays, are ongoing using a number of fresh SCLC tumors and SCLC cell lines. These studies are in progress with collaborations with several other research groups in Japan, Spain, Germany, and the U.S.


MYC suppression as a therapy for patients with small cell lung cancer

Three MYC family genes, MYCL1, MYCN and MYC, are known to be amplified in 20% of SCLCs. Therefore, we have selected these MYC family genes as strong candidates of targets for therapy for SCLC, and are investigating the biological significance of MYC family gene amplification for SCLC cells by either down-regulation of MYC family genes or suppression of their activities with several inhibitors.
 


Contact

jyokota@igtp.cat
Tel: (+34) 93 554 3050
Office 2-13, Lab 2-18 (Second Floor)
 


Cancer Genome Biology

Selected Publications

Ryan BM, Robles AI, McClary AC, Haznadar M, Bowman ED, Pine SR, Brown D, Khan M, Shiraishi K, Kohno T, Okayama H, Modali R, Yokota J, Harris CC. Identification of a functional SNP in the 3'UTR of CXCR2 that is associated with reduced risk of lung cancer. Cancer Res. 2015 Feb; 75(3): 566-75

Kurioka D, Takeshita F, Tsuta K, Sakamoto H, Watanabe S, Matsumoto K, Watanabe M, Nakagama H, Ochiya T, Yokota J, Kohno T, Tsuchiya N. NEK9-dependent proliferation of cancer cells lacking functional p53. Sci Rep 2014 Aug; 4: 6111

Umemura S, Mimaki S, Makinoshima H, Tada S, Ishii G, Ohmatsu H, Niho S, Yoh K, Matsumoto S, Takahashi A, Morise M, Nakamura Y, Ochiai A, Nagai K, Iwakawa R, Kohno T, Yokota J, Ohe Y, Esumi H, Tsuchihara K, Goto K. Therapeutic priority of the PI3K/AKT/mTOR pathway in small cell lung cancers as revealed by a comprehensive genomic analysis. J Thorac Oncol 2014 Sep; 9(9): 1324-31

Nakaoku T, Tsuta K, Ichikawa H, Shiraishi K, Sakamoto H, Enari M, Furuta K, Shimada Y, Ogiwara H, Watanabe SI, Watanabe S, Nokihara H, Yasuda K, Hiramoto M, Nammo T, Ishigame T, Schetter AJ, Okayama H, Harris CC, Kim YH, Mishima M, Yokota J, Yoshida T, Kohno T. Druggable oncogene fusions in invasive mucinous lung adenocarcinoma. Clin. Cancer Res. 2014 Jun; 20(12): 3087-93

Otsubo C, Otomo R, Miyazaki M, Matsushima-Hibiya Y, Kohno T, Iwakawa R, Takeshita F, Okayama H, Ichikawa H, Saya H, Kiyono T, Ochiya T, Tashiro F, Nakagama H, Yokota J, Enari M. TSPAN2 is involved in cell invasion and motility during lung cancer progression. Cell Rep 2014 Apr; 7(2): 527-38

Romero OA, Torres-Diz M, Pros E, Savola S, Gomez A, Moran S, Saez C, Iwakawa R, Villanueva A, Montuenga LM, Kohno T, Yokota J, Sanchez-Cespedes M. MAX inactivation in small cell lung cancer disrupts MYC-SWI/SNF programs and is synthetic lethal with BRG1. Cancer Discov 2014 Mar; 4(3): 292-303


See all

Generalitat de Catalunya

Unió Europea

CSIC

Universitat Autònoma de Barcelona

Ajuntament de Badalona

Institut Català de la Salut

Germans Trias i Pujol Hospital

Fundació Institut d'investigació en Ciències de la Salut Germans Trias i Pujol

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