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Head of Genomics and Bioinformatics Platform
Group Leader Genomics and Bioinformatics
Bachelor of Science in Biology (1989, University of Barcelona, Barcelona), he received his PhD in Biomedical Science (Lab. William B. Upholt, 1994, University de Connecticut, Farmington, Connecticut, USA) with the main interest of his doctoral thesis centered on Msx and Dlx gene regulation during vertebrate limb development. During his postdoctoral training (1994-1998, Lab. David Kimelman, Universidad de Washington, Seattle, Washington, USA) he continued studying other homeobox genes (Xnot/flh y siamois) in frogs and fish, during embryonic axis and notochord formation, describing new components of the Wnt pathway in zebrafish (like GBP). He also investigated the development of the vascular system and the influence of notochord on blood vessel formation in zebrafish.
He then switched fields to work on human genetics (1998-2001, Lab. Xavier Estivill, Institut de Recerca Oncológica, L'Hospitalet de Llobregat, Barcelona) working on mining EST databases and sequencing full length cDNA to characterize novel human gene trasncripts. From this project he started a new line of research focused on the study of an axogenesis regulator gene, LRRN6A (also known as LINGO1), co-receptor of myelin derived axonal regeneration inhibitors.
From 2001 he supervised the Microarray Unit at the Center for Genomic Regulation (CRG) Here he took part in multiple genomic studies where DNA microarray technology was applied to global gene expression profiling of mRNA or miRNA, to looking at gains and losses of genetic material by comparative genomic hybridization (aCGH), or to searching for changes in promoter binding acticity by chromatin immunoprecipitation on microarrays (CHIP on chip).
For Lauro Sumoy's publications, please see the Genomics Unit page: