IMPPC Fundación Institut de Medicina Predictiva i Personalitzada del Càncer

The main goal of the Genomics Laboratory at the IMPPC will be to provide the institution with state of the art genomics and bioinformatics technologies to give support to the activities of its researchers. We envision the gradual implementation of platforms complemented by outsourcing and contracting of external services, emphasizing the building of a team of experts in experimental design and sample preparation, and in bioinformatic data analysis. We aim to develop new methods for the discovery and typing of novel molecular markers for cancer and other disease prediction, centering on the use of DNA polymorphisms (SNPs and CNVs), differential gene expression (specifically of miRNAs and other non-coding RNAs), and chromatin modifications (DNA methylation), and the generation of predictors based on genomic data that can have an application on cancer preventive medicine.

 

Projects

Phase I in the first part of 2009 we will be setting up Genomics Unit.

Available Resources

Main emphasis will be in covering technological areas related to the study of nucleic acids with high throughput / high information content approaches, including the use of DNA chips or microarrays, genotyping assays, quantitative PCR based quantitation methods, and conventional, second and third generation DNA sequencing. 

Funding

IMPPC core funding 

Collaborations

CRG, University of BarcelonaIDIBELL, CREAL, Hospital Trias i Pujol, IR Vall d'Hebron 

Contact

lsumoy @ imppc.org

Selected Publications

1. Mercader JM, Lozano JJ, Sumoy L, Dierssen M, Visa J, Gratacòs M, Estivill X. (2008) Hypothalamus transcriptome profile suggests an anorexia-cachexia syndrome in the anx/anx mouse model. Physiol Genomics. 35(3):341-50

2. Pluvinet R, Olivar R, Krupinski J, Herrero-Fresneda I, Luque A, Torras J, Cruzado JM, Grinyó JM, Sumoy L, Aran JM (2008) CD40: an upstream master switch for endothelial cell activation uncovered by RNAi-coupled transcriptional profiling. Blood. 112(9):3624-37

 

3. Puigdecanet E, Espinet B, Lozano JJ, Sumoy L, Bellosillo B, Arenillas L, Alvarez-Larrán A, Solé F, Serrano S, Besses C, Florensa L. (2008) Gene expression profiling distinguishes JAK2V617F-negative from JAK2V617F-positive patients in essential thrombocythemia. Leukemia. 22(7):1368-76

 

4. Saenz L, Lozano JJ, Valdor R, Baroja-Mazo A, Ramirez P, Parrilla P, Aparicio P, Sumoy L, Yélamos J. (2008) Transcriptional regulation by poly(ADP-ribose) polymerase-1 during T cell activation. BMC Genomics.;9:171

 

5. Armengol G, Eissa S, Lozano JJ, Shoman S, Sumoy L, Caballin MR, Knuutila S. (2007) Genomic imbalances in Schistosoma-associated and non-Schistosoma-associated bladder carcinoma. An array comparative genomic hybridization analysis. Cancer Genet Cytogenet. 177(1):16-9

 

6. Mengual L, Burset M, Ars E, Ribal MJ, Lozano JJ, Minana B, Sumoy L, Alcaraz A. (2006) Partially Degraded RNA from Bladder Washing is a Suitable Sample for Studying Gene Expression Profiles in Bladder Cancer. Eur Urol. 50(6):1347-55

 

7. Camps J, Armengol G, del Rey J, Lozano JJ, Vauhkonen H, Prat E, Egozcue J, Sumoy L, Knuutila S, Miro R. (2006) Genome-wide differences between microsatellite stable and unstable colorectal tumors. Carcinogenesis. 27(3):419-28

 

8. de Nadal E, Zapater M, Alepuz PM, Sumoy L, Mas G, Posas F (2004) The Hog1 MAP kinase recruits the Rpd3 histone deacetylase to activate osmoresponsive genes. Nature 427:370-374