Group Leader Genetic Variation and Cancer, IMPPC

Eduard serra


Dr Serra took his first degree at the University of Barcelona in 1995, where he also received his doctorate in 2001. His thesis described his work on neurofibromas, benign tumors of the peripheral nervous system; which, when multiple, are associated with Neurofibromatosis type 1 (NF1). This work was carried out at the Department of Genetics, Hospital Clínic Barcelona and also at the Institute for Oncology Research (IRO) in Barcelona and contributed to the understanding of the mutational mechanisms inactivating NF1 in these tumors and the identification of Schwann cells as the carriers of the double inactivation of the NF1 gene. In 2001 he moved to the Molecular Sciences Institute in Berkeley, California and participated in an interdisciplinary research project "The Alpha Project" a systems biology effort that aimed to understand fundamental quantitative behaviors of a prototypic signal transduction pathway, the yeast pheromone response system. From there he returned to Barcelona in 2005 to continue postdoctoral work at the IDIBELL, Barcelona. He became a FIS Investigator in 2006 and in 2009 Dr Serra was appointed as Junior Group Leader in the IMPPC. He leads the Genetic Variation and Cancer Group and is the Scientific Coordinator of the Genetic Diagnostics Unit at IMPPC of the ICO-IMPPC Joint Program on Hereditary Cancer.

Currently his work is centered in the molecular pathogenesis of Neurofibromatoses, particularly in the genomic analysis of associated tumors and also in the translational research for hereditary cancer.

Link to the Genetic Variation and Cancer Group page
Link to the Genetic Diagnostics Unit: Genetic Testing for Hereditary Cancer

5 Selected Publications

Semiautomated Microsatellite Multiplex PCR Analysis Applied To Tumor Genetics: Detection Of Allelic Imbalances, Copy Number Assessment And Estimation Of Percentage Of Mutated Cells Within Tumors
Carles Garcia-Linares, Jaume Mercadé, Bernat Gel, Josep Biayna, Ernest Terribas, Conxi Lázaro, Eduard Serra
PLoS ONE (2012) 7(8):e42682

Dissecting Loss of Heterozygosity (LOH) In Neurofibromatosis Type 1-Associated Neurofibromas: Importance Of Copy Neutral LOH
Carles Garcia-Linares, Juana Fernández-Rodríguez, Ernest Terribas, Jaume Mercadé, Eva Pros, Llúcia Benito, Yolanda Benavente, Gabriel Capellà, Anna Ravella, Ignacio Blanco, Hildegard Kehrer-Sawatzki, Conxi Lázaro and Eduard Serra
Human Mutat 2011 32(1):78-90

Somatic NF1 Mutations in Tumors and Other Tissues
Raedt T, Maertens O, Serra E, Legius E
Monogr Hum Genet (2008) 16: 143-15 KEY: CL

Tumor LOH analysis provides reliable linkage information for prenatal genetic testing of sporadic NF1 patients.
Serra E, Pros E, García C, López E, Gili ML, Gómez C, Ravella A, Capellá G, Blanco I, Lázaro C.
Genes Chromosomes Cancer. 2007 Sep;46(9):820-7

Mitotic recombination effects homozygosity for NF1 germline mutations in neurofibromas.
Serra E, Rosenbaum T, Nadal M, Winner U, Ars E, Estivill X, Lázaro C.
Nat Genet. 2001 Jul;28(3):294-6