Director of the Hereditary Cancer Program, Catalan Institute of Oncolgoy (ICO-IDIBELL)

Gabriel Capellá obtained his medical degree from the University of Barcelona in 1983. He trained as a general and digestive surgeon at the Hospital de Sant Pau, Barcelona, between 1984 and 1988. He is also accredited in Human Genetics by the Spanish Society of Human Genetics. His interest in translational cancer research lead him to a postdoctoral stay with Dr. Manuel Perucho the years 1989 and 1990, then at the California Institute of Biological Research, La Jolla, CA. Back in Spain he spent 8 years at the Gastrointestinal Research Laboratory at the Hospital de Sant Pau where he focused his research in the molecular basis of pancreatic and colorectal cancer. Since 1998 he has worked at the Catalan Institute of Oncology where he has been Director of the Translational Research Laboratory until this year. Now he is serving as Director of the Hereditary Cancer Program.

His research focuses in the study of the genetic basis of gastrointestinal cancer with a particular interest in hereditary colorectal cancer. He has been involved in the development and implementation of novel molecular tools for the diagnosis of hereditary and sporadic GI cancer. He is co-author of more than 190 peer-review international journals.

5 Selected publications

1: Tian S, Simon I, Moreno V, Roepman P, Tabernero J, Snel M, Van't Veer L, Salazar R, Bernards R, Capella G. A combined oncogenic pathway signature of BRAF, KRAS and PI3KCA mutation improves colorectal cancer classification and cetuximab treatment prediction. Gut. 2012 Jul 14. [Epub ahead of print] PubMed PMID: 22798500.

2: Pineda M, Mur P, Iniesta MD, Borràs E, Campos O, Vargas G, Iglesias S, Fernández A, Gruber SB, Lázaro C, Brunet J, Navarro M, Blanco I, Capellá G. MLH1 methylation screening is effective in identifying epimutation carriers. Eur J Hum Genet. 2012 Jul 4. doi: 10.1038/ejhg.2012.136. [Epub ahead of print] PubMed PMID: 22763379.

3: Borràs E, Pineda M, Brieger A, Hinrichsen I, Gómez C, Navarro M, Balmaña J, Cajal TR, Torres A, Brunet J, Blanco I, Plotz G, Lázaro C, Capellá G. Comprehensive functional assessment of MLH1 variants of unknown significance. Hum Mutat. 2012 Jun 26. doi: 10.1002/humu.22142. [Epub ahead of print] PubMed PMID: 22736432.

4: Castellsagué E, González S, Guinó E, Stevens KN, Borràs E, Raymond VM, Lázaro C, Blanco I, Gruber SB, Capellá G. Allele-specific expression of APC in adenomatous polyposis families. Gastroenterology. 2010 Aug;139(2):439-47, 447.e1. Epub 2010 Apr 29. PubMed PMID: 20434453; PubMed Central PMCID: PMC2910837.

5: Menéndez M, González S, Obrador-Hevia A, Domínguez A, Pujol MJ, Valls J, Canela N, Blanco I, Torres A, Pineda-Lucena A, Moreno V, Bachs O, Capellá G. Functional characterization of the novel APC N1026S variant associated with attenuated familial adenomatous polyposis. Gastroenterology. 2008 Jan;134(1):56-64. Epub 2007 Oct 10. PubMed PMID: 18166348.

Link to the Hereditary Cancer Program at the ICO