Challenges, Opportunities and Perspectives

CosmoCaixa, Barcelona 21-22 Nov 2013


Thursday 21 November

9.15 - 9.30

Welcome from the Organizers

9.30 - 11.10

Session 1: Molecular EpigeneticsChair: Miguel Beato

Thomas Jenuwein

Max-Planck-Institute of Immunology and Epigenetics, Germany
Interstitial heterochromatin in the mouse embryonic stem cell epigenome is defined by Suv39h-dependent H3K9me3

Oliver Cuvier

Laboratoire de Biologie Molèculaire Eucaryote (LBME) - CNRS/ University of Toulouse, France
Epigenetic Regulation of Gene Expression through Key Players of Nucleosome Dynamics

Sandra Peiró

Hospital del Mar Medical Research Institute (IMIM), Spain
Regulation of Heterochromatin Transcription by Snail1/ LOXL2 during Epithelial to Mesenchymal Transition

Kristian Helin

Biotech research and Innovation Centre, Denmark
Mechanisms regulating Polycomb group proteins to target genes

11.10 - 11.40
Coffee Break
11.40 - 13.10

Session 2: Epigenetic mechanisms of differentiation & developmentChair: Albert Jordan

Raffaella Santoro

University of Zurich, Switzerland
The epigenetics of the nucleolus

Antonis Kirmizis

Department of Biological Sciences, University of Cyprus, Nicosia, Cyprus
The histone N-terminal acetyltransferase Nat4 controls ribosomal DNA expression and cell growth

Jeffrey Dilworth

Ottawa Hospital Research Institute, Canada
Trr-like trithorax complex is critically required for satellite cells mediated muscle regeneration

Marcus Buschbeck

Institute of Predictive and Personalized Medicine of Cancer (IMPPC), Spain
A non-canonical function for a Polycomb protein in embryonic stem cell

13.10 - 14.40
Lunch and Poster Session
14.40 - 16.10

Session 3: Aberrant patterns of chromatin modification in cancerChair: Ferran Azorin

Andrew Feinberg

Johns Hopkins University, Baltimore, USA
Large scale epigenomic changes in human cancer

Angela Risch

DKFZ German Cancer Research Center, Heidelberg, Germany
From genome-wide analyses to epigenetic mechanisms in lung carcinogenesis

Angelika Merkel

National Center for Genomic Analysis (CNAG), Barcelona, Spain
Non CpG methylation during normal Bcell differentiation

Manuel Perucho

Institute of Predictive and Personalized Medicine of Cancer (IMPPC), Barcelona, Spain
Somatic DNA methylation alterations in colorectal cancer

16.10 16.40
Coffee Break
16.40 - 18.20

Session 4: Stem Cells & CancerChair: Manuel Perucho

Marjorie Brand

Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute, Canada
UTX is required for TAL1-mediated leukemogenesis in T-ALL

Luciano Di Croce

ICREA and the Center for Genomic Regulation (CRG), Spain
Dissecting the role of Polycomb in embryonic stem cell and cancer

Rudolf Jaenisch

EMBO Keynote Lecture

Whitehead Institute, MIT, USA
iPS Cell Technology and Disease Research: Issues to be Resolved

18.20 - 20.00

Poster Session and Networking

Friday 22 November

09.30 - 11.10

Session 5: EpigeneticsChair: Marcus Buschbeck

09.30 - 11.10

Bing Ren

University of California, San Diego, USA
High Resolution Analysis of Three-dimensional Genome Architecture in Human Cells

Henk Stunnenberg

Radboud University, Netherlands
The epigenome of groundstate mouse embryonic stem cells

Marc Martí Renom

National Center for Genomic Analysis (CNAG), Barcelona, Spain
Functional role of Topologically Associating Domains in the dynamic response of breast cancer cells to hormone

Amos Tanay

EMBO Young Investigator Lecture

Weizmann Institute of Science, Israel
Maintenance of epigenetic memory in pluripotent, somatic and tumor cells

11.10 - 11.40
Coffee Break
11.40 - 13. 20

Session 6: Epigenetic mechanisms as point of therapeutic interventionChair: Manel Esteller

Tony Kouzarides

Gurdon Institute Cambridge, UK
Epigenetic modifications in transcription and cancer

Manel Esteller

Epigenetic and Cancer Program (PEBC-IDIBELL), Spain
Cancer Epigenetics: From Knowledge to Applications

Manfred Jung

Institute of Pharmaceutical Sciences and Freiburg Institute of Advanced Studies (FRIAS), Universität Freiburg, Germany
Exploiting the HDAC subtype sensitivity of S. mansoni for epigenetic antiparasite drugs

Carlo M. Croce

Josep Carreras Leukaemia Research Institute Lecture

Ohio State University, USA
Causes and consequences of microRNA dysregulation in cancer


Closing Remarks