PRELIMINARY PROGRAM

The organizers reserve the right to make changes to this program if circumstances require.

The titles given her are orientative, please consult this page for program updates.

Thursday 3 May

09.00-09.30

Opening of conference and Welcome remarks
Introduction by Juan Valcárcel, Director RNAREG Consortium
Introduction by Manuel Perucho, Director IMPPC

09.30-11.35

Session I: Regulation of Post Transcriptional Control of Gene Expression: an overview

09.30-09.35

Chair: Mayka Sanchez, IMPPC, RNAREG, Spain

09.35-10.10

Adrian Krainer
Cold Spring Harbor Laboratory, New York, USA
SRSF1: A Splicing Factor Oncoprotein

10.10-10.45

Matthias W. Hentze
The European Molecular Biology Laboratory (EMBL), Germany
Regulatory RNA-binding Proteins: from Complete mRNA Interactomes to REM Networks

10.45-11.20

Mayka Sanchez
IMPPC, RNAREG, Spain
Iron Regulatory Proteins and Iron-Response Elements: New Frontiers

11.20-11.35

Laurence Wurth.
RNAREG, Spain
A role of the conserved RNA binding protein UNR in cancer progression

11.35-12:10

Coffee

12.10-14.30

Session II: RNA Splicing, Processing, Quality control and decay: Mechanism and diseases

12.10-12.15

Chair: Raúl Mendez, RNAREG, Spain

12.15-12.50

Tom Cooper
Baylor College of Medicine, Houston, USA
Alternative Splicing Regulatory Networks in Development and Disease

12.50-13.25

Reuven Agami
The Netherlands Cancer Institute, Amsterdam, The Netherlands
Alternative poly-adenylation: Genomic and molecular analyses provide clues to a genetic disease

13.25-14.00

Andreas Kulozik
Kinderklinik University Heidelberg, Germany
Regulated 3' end Processing – Implications for the Control of Blood Coagulation, Innate Immunity and Tumor Spread

14.00-14.15

Vittorio Calderone
RNAREG, Spain
Unveiling a new mechanism of regulation of angiogenesis through translational regulation by the CPEB family of proteins

14.15-14.30

Victor Quesada
RNAREG, Spain
Frequent somatic mutations in components of the RNA processing machinery in chronic lymphocytic leukemia

14.30-15.30

Lunch and poster session

15.30-17.50

Session III: Short non-coding RNAs in cancer and diseases

15.30-15.35

Chair: Lauro Sumoy, IMPPC, Spain

15.35-16.10

Carlo Croce
Human Cancer Genetics Program, Ohio State University, USA
Causes and Consequences of microRNA Dysregulation in Cancer

16.10-16.45

Javier Cáceres
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, UK
Regulation of microRNA Biogenesis and Function

16.45-17.20

Gunter Meister
Department of Biochemistry I, Faculty of Biology and Preclinical Medicine, University of Regensburg, Germany
The role of miRNAs in glioblastoma

17.20-17.35

Regine Schneider-Stock
University of Erlangen-Nürnberg, Germany
Biochemical and functional characterization of inflammation-associated miRNA 26b

17.35-17.50

Monica Bañez-Coronel
Centre for Genomic Regulation (CRG), Spain
A pathogenic mechanism in Huntington's disease involves small CAG-repeated RNAs with neurotoxic activity

17.50-18.20

Coffee

18.20-19.35

Session IV: Circulating and exosomal miRNAs and cancer

18.20-18.25

Chair: Fatima Gebauer RNAREG, Spain

18.25-19.00

Lauro Sumoy
IMPPC, Spain
Next Generation Sequencing Analysis of miRNA Isomir Heterogeneity in Serum

19.00-19.35

CY Zhang
Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, Nanjing University, China
Circulating MicroRNAs, Secreted MicroRNAs and exogenous plant microRNA

19.35-20.15

Cocktail and posters

Friday 4 May

09.00-10.50

Session V: Long non-coding RNAs in cancer and diseases

09.00-09.05

Chair: Maite Huarte, RNAREG, Spain

09.05-09.40

John Rinn
Department of Pathology, Beth Israel and Deaconess Medial Center and the Department of Stem Cell and Regenerative Biology, Harvard Medical School and The Broad Institute of Harvard and MIT, USA
Linking RNA to Human Health and Disease

09.40-10.15

Denise Barlow
CeMM Research Center for Molecular Medicine of the Austrian Academy of Science, Austria
Macro Unspliced lncRNAs in Imprinted Gene Clusters in the Mouse and Human Genome

10.15-10.50

Manel Esteller
Programa de Epigenética y Biología del Cáncer (PEBC) del Instituto de Investigaciones Biomedicas de Bellvitge (IDIBELL), Barcelona, Spain
Epigenetic and Genetic Disruption of Non-Coding RNAs in Human Disease

10.50-11.20

Coffee

11.20-12.50

Session VI: RNA Therapeutics

11.20-11.25

Chair: Marisol Soengas RNAREG, Spain

11.25-13.00

Luigi Naldini
San Raffaele Telethon Institute for Gene Therapy, Italy
miRNA regulation in gene therapy

13.00-13.35

Susanna Obad
MicroRNA Research at Santaris Pharma, Hørsholm, Denmark
Targeting of microRNAs for Therapeutics

13.35-13.50

Vicente Marchan
University of Barcelona, Spain
Towards RNA-targeted anticancer ruthenium(II) arene complexes via conjugation to small molecules

13.50

Closing Remarks