The organizers reserve the right to make changes to this program if circumstances require.

Thursday 31 March

09.00 - 09.30

Opening of Conference and welcome remarks

Introduction by Manuel Perucho, Director IMPPC

Sr. Antoni Castellà, Secretary of Research and Universities, Government of Catalonia

09.30 - 11.10

Session 1: Signal transduction - from the plasma membrane to chromatinChair: Marcus Buschbeck

Axel Ullrich, Max-Planck-Institute of Biochemistry, Germany
FGFR4 is an enhancer of EGFR oncogenic signaling
Erwin Wagner, Spanish National Cancer Research Centre (CNIO), Spain
Cancer and Inflammation: Functions of AP-1 (Fos/Jun) in mice and human
Miguel Beato, Centre for Genomic Regulation (CRG), Spain
Hormone Signaling to Chromatin in Breast Cancer Cells

11.10 - 11.40

Coffee

11.40 - 13.30

Session 2: Chromatin alterations during differentiation and cancerChair: Esteban Ballestar

Dirk Schuebeler, Friedrich Miescher Institute for Biomedical Research, Switzerland
Genetic determinants of epigenetic repression
Short talk: Iris Uribesalgo, Centre for Genomic Regulation (CRG), Spain
Connecting Pak2 activity, retinoic acid pathway and E-box independent Myc function with leukemia progression in vivo
Short talk: Ulrike Ziebold, Max-Delbrück-Center for Molecular Medicine (MDC), Germany
Wnt/β-catenin drives MLL1 activity which is critical for the epigenetic state of salivary gland cancer stem cells
Christoph Plass, German Cancer Research Center (DKFZ), Germany
Genome-wide DNA Methylation Profiles in Chronic Lymphocytic Leukemia

13.30 - 14.45

Lunch and Poster Session

14.45 - 16.20

Session 3: DNA and histone methylation in cancerChair: Fumiichiro Yamamoto

Andrew Feinberg, Johns Hopkins University School of Medicine, USA
The Epigenetic Basis of Common Human Disease
Miguel Àngel Peinado, Institute of Predictive and Personalized Medicine of Cancer (IMPPC), Spain
Insights into the role of unmethylated Alus in differentiation and cancer
Peter Jones, USC/Norris Comprehensive Cancer Center, USA
Targeting the epigenome for therapy

16.20 - 16.40

Coffee

16.40 - 18.20

Session 4: Chromatin plasticity through histone variantsChair: Albert Jordan

Sandra Hake, Adolf Butenandt Institute, Germany
Histones: how much variation do we need?
W. Lee Kraus, UT Southwestern Medical Center at Dallas, USA
The Histone Variant MacroH2A1: Genomic Localization, Interacting Proteins, and Nuclear Functions
Marcus Buschbeck, Institute of Predictive and Personalized Medicine of Cancer (IMPPC), Spain
An extraordinary histone variant regulating lineage commitment
Short talk: Zuzana Jasencakova, Biotech Research and Innovation Centre (BRIC), Denmark
Replication stress, a threat to epigenetic stability?

18.20 - 20.00

Poster session, Networking and Cocktail

Friday 1 April

09.00 - 10.30

Session 5: Mechanisms of chromatin regulationChair: Miguel Àngel Peinado

Peter Becker, Adolf Butenandt Institute, Germany
Nucleosome remodelling by CHRAC/ACF: from Drosophila development to the mammalian DNA damage response
Short talk: Manlio Vinciguerra, European Molecular Biology Laboratory (EMBL), Italy
Cardioprotective mIGF-1/SirT1 signaling and genomics
Wendy Bickmore, MRC Human Genetics, Western General Hospital, Scotland
Chromatin mediated regulation of gene expression: beyond histone modifications and transcription initiation

10.30 – 11.00

Coffee

11.00 – 12.35

Session 6: Regulation by Polycomb complexesChair: Luciano Di Croce

Maarten van Lohuizen, Netherlands Cancer Institute (NKI), Netherlands
Role of Polycomb repressors in stem cells, cancer and development
Diego Pasini, , European Institute of Oncology (IFOM-IEO), Italy
Mechanisms of Polycomb Mediated Transcriptional Repression
Short talk: Holger Richly, Centre for Genomic Regulation (CRG)
Transcriptional activation of polycomb-repressed genes by ZRF1
Short talk: Salvador Aznar Benitah, Centre for Genomic Regulation (CRG), Spain
Role of Jumonji and Cbx proteins in epidermal stem cell homeostasis

12.35

Closing Remarks

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